کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
28997 44112 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Production of reactive oxygen species induced by a new [60]fullerene derivative bearing a tetrazole unit and its possible biological applications
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Production of reactive oxygen species induced by a new [60]fullerene derivative bearing a tetrazole unit and its possible biological applications
چکیده انگلیسی

The wide range of physical and chemical properties of modified fullerenes has drawn increasing attention in the past few years. As part of this research, this paper describes the preparation, characterization, and photophysical properties of a new fullerene derivative chemically modified with a tetrazole. The photophysical properties were studied by EPR radical spin-trapping technique and showed that reactive oxygen species (ROS) can be produced through UVA photosensitization. EPR spin-trapping experiments with singlet oxygen (1O2) and superoxide (O2−) inhibitors (β-carotene and superoxide dismutase, respectively) revealed also that: (i) the main ROS produced is 1O2 and (ii) 1O2 is being partially dismutated to O2−. The results suggest that this derivative can be used in biological applications, as for example, in topic photodynamic therapy (PDT) as a photosensitizer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 200, Issues 2–3, 15 December 2008, Pages 277–281
نویسندگان
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