Underestimation of extent of ischemia by gated SPECT myocardial perfusion imaging in patients with left main coronary artery disease

The findings of this study demonstrate that assessment of perfusion data alone by visual or quantitative SPECT MPI analysis underestimates the magnitude of left main CAD. The combination of perfusion and nonperfusion abnormalities on gated MPI identifies high risk in most patients with left main CAD.