کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3001826 | 1180679 | 2015 | 10 صفحه PDF | دانلود رایگان |
• This study was to evaluate the effect of beta-glucan on various lipid parameters in hypercholesterolemic subjects.
• Beta-glucan consumption in hypercholesterolemic population significantly lowered the TC and LDL-cholesterol concentration.
• No adverse effects were reported among the eligible trials.
Background & aimsA growing body of evidence suggests that beta-glucan derived from oats or barley can reduce cardiovascular disease risk through reductions in serum lipids. However, the effects of beta-glucan on lipid changes in hypercholesterolemic patient groups are inconsistent. The objective of this study was to identify and quantify the effect of beta-glucan, a marker of water-soluble fiber, on various lipid parameters and glucose level in hypercholesterolemic subjects.Methods and resultsWe performed a comprehensive literature search to identify the relevant randomized controlled trials (RCTs) that investigated the effects of beta-glucan consumption in hypercholesterolemic subjects. Mean differences (MDs) and 95% confidence intervals (CIs) were calculated for net changes in lipid concentrations by using fixed-effects or random-effects models according to heterogeneity. Publication bias, sensitivity analysis and subgroup analyses were also performed. Seventeen eligible RCTs with 916 subjects were included in the meta-analysis. The pooled result showed that beta-glucan consumption in hypercholesterolemic population significantly lowered the total cholesterol (TC) (MD, −0.26 mmol/L; 95% CI, −0.33 to −0.18; P < 0.00001) and low-density lipoprotein (LDL)-cholesterol concentration (MD, −0.21 mmol/L; 95% CI, −0.27 to −0.14; P < 0.00001). However, there were no significant differences in high-density lipoprotein (HDL)-cholesterol, triglycerides (TG) and glucose. No adverse effects were reported among the eligible trials.ConclusionOur meta-analysis showed that beta-glucan consumption significantly decreased TC and LDL-cholesterol concentrations but did not affect TG, HDL-cholesterol, and glucose concentrations in hypercholesterolemic subjects.
Journal: Nutrition, Metabolism and Cardiovascular Diseases - Volume 25, Issue 8, August 2015, Pages 714–723