کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3003157 1180770 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of oleic acid and macrophage recruitment on cholesterol efflux in cell culture and in vivo
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Effects of oleic acid and macrophage recruitment on cholesterol efflux in cell culture and in vivo
چکیده انگلیسی

Background and aimMonounsaturated fatty acids in diets are beneficial for the plasma lipoprotein profile, but studies in cell culture point out that they may also be detrimental by inhibiting cholesterol efflux to apo AI.Methods and ResultsIn the present study we used mouse peritoneal macrophages, loaded with cholesterol and upregulated by cyclic AMP or by LXR/RXR ligands and compared the effect of oleic acid on cholesterol efflux to 3 different acceptors. Inhibition of cholesterol efflux by oleic acid ranged from 10 to 25% with HDL or 2.5% mouse serum, while efflux to phosphatidyl choline vesicles was not affected. Previously we reported that the LXR ligand, TO901317, retarded cholesterol removal in vivo from a modified LDL depot in muscle. This could have resulted from inhibition by unsaturated fatty acids or from reduction in macrophage recruitment due to the anti-inflammatory action of LXR.ConclusionsOur current findings, of retardation of cholesterol clearance from the depot in the presence of low macrophage recruitment, support the latter possibility.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition, Metabolism and Cardiovascular Diseases - Volume 18, Issue 9, November 2008, Pages 596–601
نویسندگان
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