Cellules T régulatrices et lupus érythémateux systémique

A global depletion of FoxP3+ CD25bright CD4+ regulatory T cell is observed during lupus flares. This phenomenon is not the consequence of the relocalization of Tregs in diseased organs but could be related to their specific sensitivy to Fas mediated apoptosis. Several therapeutic perspectives can be drawn taking into account these pathophysiological insights.