کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3036132 1184357 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oscillatory activity in basal ganglia and motor cortex in an awake behaving rodent model of Parkinson's disease
ترجمه فارسی عنوان
فعالیت نوسانی در گانگلیس های پایه و قشر حرکتی در یک مدل رفتار جوشی نابارور از بیماری پارکینسون
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی

Exaggerated beta range (15–30 Hz) oscillatory activity is observed in the basal ganglia of Parkinson's disease (PD) patients during implantation of deep brain stimulation electrodes. This activity has been hypothesized to contribute to motor dysfunction in PD patients. However, it remains unclear how these oscillations develop and how motor circuits become entrained into a state of increased synchronization in this frequency range after loss of dopamine. It is also unclear whether this increase in neuronal synchronization actually plays a significant role in inducing the motor symptoms of this disorder. The hemiparkinsonian rat has emerged as a useful model for investigating relationships between loss of dopamine, increases in oscillatory activity in motor circuits and behavioral state. Chronic recordings from these animals show exaggerated activity in the high beta/low gamma range (30–35 Hz) in the dopamine cell-lesioned hemisphere. This activity is not evident when the animals are in an inattentive rest state, but it can be stably induced and monitored in the motor cortex and basal ganglia when they are engaged in an on-going activity such as treadmill walking. This review discusses data obtained from this animal model and the implications and limitations of this data for obtaining further insight into the significance of beta range activity in PD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Basal Ganglia - Volume 3, Issue 4, April 2014, Pages 221–227
نویسندگان
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