کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3039525 | 1579674 | 2016 | 6 صفحه PDF | دانلود رایگان |
• IDH1 mutation is related with preoperative seizure in low-grade gliomas.
• Preoperative seizure odds ratio is not affected by preoperative seizure incidence.
• Preoperative seizure odds ratio is not affected by IDH1 mutation rate.
ObjectiveThe aim of this analysis was to perform a meta-analysis assessing the relationship between isocitrate dehydrogenase 1 (IDH1) mutation and preoperative seizure in low-grade gliomas.MethodsSystematic computerised searches of the PubMed and Web of Knowledge were performed. The meta-analysis of pooled odds ratio (OR) and 95% confidence interval (CI) for preoperative seizure risk stratified by IDH1 mutation status were calculated.ResultsFive studies with 540 patients were included for meta-analysis. The preoperative seizure incidence ranged from 73.54% to 94.12% in the IDH1 Mutation (+) group, compared 37.50%–76.92% in the IDH1 Mutation (−) group. The pooled crude OR was 2.750 (95% CI 1.763–4.290; Z = 4.46, P = 0.000). The Begg’s test (z = 0.73, P = 0.462), the Egger's test (t = 0.41, P = 0.708) and symmetrical funnel plot suggested no significant publication bias. Sensitivity analysis by only pooled adjusted ORs showed the pooled OR was 2.740 (95% CI 1.593–4.714; Z = 3.64, P = 0.000) which indicated the results were robust. Meta-regression analysis showed preoperative seizure OR was not related with preoperative seizure incidence (t = 0.37, P = 0.736), and not related with IDH1 mutation rate (t = 1.85, P = 0.162).ConclusionOur meta-analysis indicated that IDH1 mutation was related with preoperative seizure in low-grade gliomas.
Journal: Clinical Neurology and Neurosurgery - Volume 148, September 2016, Pages 79–84