کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3041187 1184764 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pyramidal and extrapyramidal scale (PEPS): A new scale for the assessment of motor impairment in vascular cognitive impairment associated with small vessel disease
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Pyramidal and extrapyramidal scale (PEPS): A new scale for the assessment of motor impairment in vascular cognitive impairment associated with small vessel disease
چکیده انگلیسی

ObjectiveVascular cognitive impairment associated with small vessel disease (sVCI) may manifest as both cognitive and motor dysfunctions. However, few instruments exist for systematically assessing motor symptoms in sVCI, even though many neuropsychological tests exist to evaluate cognitive function. We developed a new scale for assessing motor impairments and evaluated the reliability and validity of the scale in patients with sVCI.MethodsA new motor scale, called the PEPS (Pyramidal and Extra Pyramidal Scale for sVCI), consisted of 34 items (for 60 total points) with 5 subdomains: corticospinal, corticobulbar, extrapyramidal signs, gait abnormalities, and gait severity. The PEPS was compared between 75 patients with sVCI and 73 control patients who had dementia or mild cognitive impairment (MCI) without ischemia.ResultsThe PEPS had good interrater and test–retest reliability, and it was moderately to highly correlated with the UPDRS, NIHSS, MMSE, CDR, and ADL scales. An optimal cut-off score of PEPS to discriminate dementia or MCI patients with ischemia from those without ischemia was 6.5 with a sensitivity of 88% and a specificity of 100%.ConclusionThe PEPS is a reliable and valid scale that can be used to assess and monitor motor impairment in patients with vascular cognitive impairment due to small vessel disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurology and Neurosurgery - Volume 113, Issue 3, April 2011, Pages 181–187
نویسندگان
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