کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3041695 1184787 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tumor–platelet interactions: Glioblastoma growth is accompanied by increasing platelet counts
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Tumor–platelet interactions: Glioblastoma growth is accompanied by increasing platelet counts
چکیده انگلیسی

ObjectivesWe have recently shown that pre-operative thrombocytosis is associated with significantly shorter survival in patients with glioblastoma (GBM). The interaction between platelets and growth of GBM is not clear yet. One hypothesis suggests that platelet-released growth factors support growth and migration of malignant glioma and endothelial cells and thus may increase angiogenesis in these tumors. Another hypothesis would be that larger tumors are associated with poorer survival and produce more factors inducing thrombocytosis. In this study we investigate whether GBM growth induces thrombocytosis.Patients and methodsWe compared pre-operative platelet counts of 24 patients with GBM with platelet counts taken 46.3 ± 29.2 months (mean ± 1S.D.) prior to diagnosis of GBM.ResultsWe found immediate pre-operative platelet counts to be significantly higher than the older platelet counts (p = 0.02). Furthermore, patients with GBM at time of diagnosis presented with increased platelet counts (314 ± 86 platelets/nl) compared to the normal population.ConclusionOur results suggest that elevation of platelet counts in glioblastoma patients is caused by growth and development of GBM. Whether tumor secreted cytokines are the underlying mechanism for this finding, remains to be elucidated.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurology and Neurosurgery - Volume 110, Issue 4, April 2008, Pages 339–342
نویسندگان
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