کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3041724 1184788 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Plasma glutamate and glycine levels in patients with amyotrophic lateral sclerosis: The effect of riluzole treatment
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Plasma glutamate and glycine levels in patients with amyotrophic lateral sclerosis: The effect of riluzole treatment
چکیده انگلیسی

ObjectivesDefective glutamate (glu) metabolism and excitotoxicity have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). Moreover, glycine (gly) has been shown to potentiate excitatory transmission. The “antiglutamatergic” agent riluzole has been shown to prolong survival in ALS. The aim of the study was to investigate a possible effect of riluzole on plasma glu and gly levels, correlating with clinical response to treatment.Patients and methodsPlasma concentrations of glu and gly were measured in 20 healthy volunteers and 22 ALS patients before treatment and after 6 months on riluzole.ResultsAt baseline, increased plasma glu correlated with spinal onset and male gender whereas gly levels did not differ between patients and controls. No significant change was observed for both amino acids post-treatment, despite a lower rate of disease progression.ConclusionThese results suggest that riluzole may affect disease progression without a significant impact on plasma glu and gly levels, possibly indicating different mechanisms of drug action.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurology and Neurosurgery - Volume 110, Issue 3, March 2008, Pages 222–226
نویسندگان
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