کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3050935 1185968 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of uridine on kindling
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Effects of uridine on kindling
چکیده انگلیسی
The anticonvulsant effect of the nucleoside uridine has been studied for several decades with controversial results. One of its attractive properties is that as a natural endogenous molecule, it lacks the serious side effects of common antiepileptic drugs used today. In the current study, we examined the potential antiepileptogenic effect of uridine in the hippocampal kindling model, using once-daily stimulations. Uridine was administered once or three times daily; levetiracetam was administered as a positive control; and normal saline was used as a negative control. Rats receiving uridine or levetiracetam had slower kindling rates and shorter afterdischarge durations than the normal saline controls. These results are consistent with previous work using a rapid kindling model and suggest that uridine has antiepileptogenic properties. Because of its combination of low toxicity and efficacy, uridine is a possible candidate for the treatment of epilepsy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 13, Issue 1, July 2008, Pages 47-51
نویسندگان
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