کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3051222 | 1579862 | 2007 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Functional MRI characteristics of a focal region of cortical malformation not associated with seizure onset Functional MRI characteristics of a focal region of cortical malformation not associated with seizure onset](/preview/png/3051222.png)
Neuroimaging studies have demonstrated that heterotopic tissue of patients with “double cortex” is activated during motor and somatosensory tasks. Activation in patients with malformations of cortical development (MCD) has been variable, likely due to the heterogeneity of the disorder. We examined clinical, electroencephalography (EEG), neuropsychological, and functional MRI findings in a patient with intractable epilepsy secondary to MCD in the left temporal cortex. Invasive EEG monitoring revealed that the dysplastic tissue was not involved in ictal onset of seizures. Functional MRI tests of motion and object processing, memory encoding, and language demonstrated no activation within dysplastic tissue. Hemispheric asymmetries in activation for motion and object processing were evident, favoring the right hemisphere—a pattern not evident in controls. These weaker activations in the patient were present in tissue proximal to the seizure focus. Thus, nonepileptogenic dysplastic tissue may not support cognitive functions, with abnormal processing evident in epileptogenic tissue.
Journal: Epilepsy & Behavior - Volume 10, Issue 4, June 2007, Pages 615–625