کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3051884 1579872 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Everolimus and intensive behavioral therapy in an adolescent with tuberous sclerosis complex and severe behavior ★
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Everolimus and intensive behavioral therapy in an adolescent with tuberous sclerosis complex and severe behavior ★
چکیده انگلیسی

BackgroundSelf-injury and aggression have been reported in individuals with TSC (tuberous sclerosis complex), yet few data exist about treatment. Everolimus, an mTOR inhibitor, has been FDA-approved for subependymal giant cell astrocytomas (SEGAs) and renal angiomyolipomas in TSC. However, clinical use of everolimus with direct, real-time observations of self-injury and aggression in an individual with TSC has not been reported.MethodsDuring an inpatient admission to a neurobehavioral unit, real-time measurements of behaviors and seizures were recorded. An interdisciplinary team used these data to make treatment decisions and applied behavioral and pharmacological treatments, one at a time, in order to evaluate their effects.ResultsAggression and self-injury improved with applied behavioral analysis (ABA), lithium, and asenapine. Improvements in SEGA size, facial angiofibromas, seizures, and the most stable low rates of self-injury were observed during the interval of treatment with everolimus.ConclusionMechanism-based treatments in the setting of an evidence-based behavioral and psychopharmacological intervention program may be a model with utility for characterization and treatment of individuals with severe behavior and TSC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior Case Reports - Volume 1, 2013, Pages 122–125
نویسندگان
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