کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3051892 1579872 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
EEG–fMRI findings in late seizure recurrence following temporal lobectomy: A possible contribution of area tempestas
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
EEG–fMRI findings in late seizure recurrence following temporal lobectomy: A possible contribution of area tempestas
چکیده انگلیسی

Late seizure relapses following temporal lobectomy for drug-resistant temporal lobe epilepsy occur in 18–30% of operated-on cases, and recent evidence suggests that a significant proportion of them are due to maturation and activation of proepileptic tissue having defied initial resection and located at the vicinity of or at a short distance from its borders, usually over the posterior medial, basal temporal-occipital, and lateral temporal regions. Experimental studies in animals and functional imaging studies in humans suggest that the area tempestas, a particular region of the basal-frontal piriform cortex, is critical for kindling and initiation and propagation of seizure activity arising from different cortical foci, especially limbic ones. This case report of a patient with late seizure relapse, three years following an initially successful right temporal lobectomy for ipsilateral medial temporal sclerosis, is the first one in the literature to demonstrate interictal EEG–fMRI evidence of significant BOLD signal changes over the inferior, basal and lateral temporal and temporooccipital cortices posterior to the resection margin, plus a significant BOLD signal change over the ipsilateral basal frontal region, closely corresponding to the piriform cortex/area tempestas. Our case study provides further functional imaging evidence in support of maturation/activation of proepileptic tissue located at the vicinity of the initial temporal lobe resection in cases of late seizure relapses and suggests, in addition, a possible role for the piriform cortex/area tempestas in the relapsing process.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior Case Reports - Volume 1, 2013, Pages 157–160
نویسندگان
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