کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3055741 1580194 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Animal models for vagus nerve stimulation in epilepsy
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Animal models for vagus nerve stimulation in epilepsy
چکیده انگلیسی

Vagus nerve stimulation (VNS) is a moderately effective adjunctive treatment for patients suffering from medically refractory epilepsy and is explored as a treatment option for several other disorders. The present review provides a critical appraisal of the studies on VNS in animal models of seizures and epilepsy. So far, these studies mostly applied short-term VNS in seizure models, demonstrating that VNS can suppress and prevent seizures and affect epileptogenesis. However, the mechanism of action is still largely unknown. Moreover, studies with a clinically more relevant setup where VNS is chronically applied in epilepsy models are scarce. Future directions for research and the application of this technology in animal models of epilepsy are discussed.

Research Highlights
► Preclinical studies proved safety and efficacy of VNS but mode of action is unknown.
► A clinically relevant animal model to study VNS is lacking.
► Future studies should apply chronic VNS in chronic epilepsy models.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Neurology - Volume 230, Issue 2, August 2011, Pages 167–175
نویسندگان
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