کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3055827 | 1186539 | 2011 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Nucleus accumbens facilitates nociception Nucleus accumbens facilitates nociception](/preview/png/3055827.png)
We have previously demonstrated an opioid link in nucleus accumbens (NAc) that mediates antinociception produced by a novel ascending pain modulation pathway. For example, noxious stimulation induces heterosegmental antinociception that is mediated by both mu- and delta-opioid receptors in NAc. However, spinal intrathecal administration of the mu-receptor agonist [d-Ala2, N-Me-Phe4,Gly5-ol]-enkephalin (DAMGO) also induces heterosegmental antinociception. The aim of the present study in the rat was to identify the intra-NAc opioid receptors that mediate the antinociceptive effects of spinally administered DAMGO and also to determine the effect of NAc efferent activity on nociception. Intra-NAc administration of either the mu-opioid receptor antagonist Cys2,Tyr3, Orn5,Pen7amide (CTOP) or the delta-opioid receptor antagonist naltrindole blocked the antinociceptive effect of spinally administered DAMGO on the jaw-opening reflex (JOR). Injection of quaternary lidocaine (QX-314) attenuated the JOR, suggesting that the output of NAc is pronociceptive. In support of this, intra-NAc injection of the excitatory amino acid agonist kainate enhanced the JOR. Thus, it is possible to modulate activity in NAc to bidirectionally attenuate or enhance nociception, suggesting a potential role for NAc in setting nociceptive sensitivity.
Research highlights
► Spinal intrathecally administered DAMGO induces heterosegmental antinociception.
► Opioid receptors in nucleus accumbens mediate this effect.
► Intra-accumbens lidocaine attenuates nociceptive responses.
► Intra-accumbens kainate facilitates nociceptive responses.
► Nucleus accumbens may be important in controlling pain sensitivity.
Journal: Experimental Neurology - Volume 229, Issue 2, June 2011, Pages 502–506