کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3056268 | 1186560 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Attenuated neurotoxicity of the transactivation-defective HIV-1 Tat protein in hippocampal cell cultures
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Attenuated neurotoxicity of the transactivation-defective HIV-1 Tat protein in hippocampal cell cultures Attenuated neurotoxicity of the transactivation-defective HIV-1 Tat protein in hippocampal cell cultures](/preview/png/3056268.png)
چکیده انگلیسی
This study reports that the cysteine 22 → glycine 22 substitution in the HIV-1 Tat 1–86 B significantly attenuates its neurotoxicity. Consistent with previous studies, direct interactions of rat hippocampal cells with Tat 1–86 B were shown to cause dose-dependent and time-dependent neurotoxicity associated with activation of caspases from the mitochondrial apoptotic pathway. Despite the similar binding/uptake properties, Cys22 Tat 1–86 B failed to induce significant neurotoxicity and activation of caspases 9 and 3/7 in hippocampal primary cultures. Results of the study underscore the important role of cysteine-rich domain in mechanism of Tat-mediated neurotoxicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Neurology - Volume 219, Issue 2, October 2009, Pages 586–590
Journal: Experimental Neurology - Volume 219, Issue 2, October 2009, Pages 586–590
نویسندگان
Michael Y. Aksenov, Marina V. Aksenova, Charles F. Mactutus, Rosemarie M. Booze,