کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3064655 | 1580447 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CD200 receptors are differentially expressed and modulated by minocycline in the brain during Trypanosoma brucei infection
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: CD200 receptors are differentially expressed and modulated by minocycline in the brain during Trypanosoma brucei infection CD200 receptors are differentially expressed and modulated by minocycline in the brain during Trypanosoma brucei infection](/preview/png/3064655.png)
چکیده انگلیسی
Infection with Trypanosoma brucei, which causes African trypanosomiasis, activates microglia, which are constitutively maintained in a quiescent state through CD200–CD200 receptor interactions. C57BL/6 mice have one inhibitory receptor, CD200R and three activating members, CD200 receptor-like (RL)a–c. Infection increased MAC-1 (microglia marker), CD200RLa and CD200RLb, but not CD200, CD200R or CD200RLc, transcript levels in the brains. Minocycline treatment inhibited the infection-induced elevation of MAC-1 and CD200RLa transcripts, but had no significant effect on CD200 or the other receptors. This suggests that CD200RLa might play a role in microglia/macrophage activation during trypanosome infection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 226, Issues 1–2, 14 September 2010, Pages 59–65
Journal: Journal of Neuroimmunology - Volume 226, Issues 1–2, 14 September 2010, Pages 59–65
نویسندگان
Willias Masocha,