کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3069557 1580677 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Gene therapy for amyotrophic lateral sclerosis
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Gene therapy for amyotrophic lateral sclerosis
چکیده انگلیسی

Gene therapy continues to be a potential option for amyotrophic lateral sclerosis (ALS). This chapter will inform the reader about promising therapeutic transgenes and proof-of-principle studies in transgenic rodent models of ALS. Challenges regarding the disease targets and time for therapeutic intervention will be also discussed. Finally, restorative therapy for ALS, as well as gene therapy for other motor neuron diseases will be briefly reviewed.


► Therapeutic target: motor neurons, glial, and/or skeletal muscles.
► Transgenic models of ALS.
► Gene delivery approaches to motor neurons.
► Therapeutic transgenes.
► Parallel approaches.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Disease - Volume 48, Issue 2, November 2012, Pages 236–242
نویسندگان
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