کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3069781 1580701 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inverse association between CSF Aβ 42 levels and years of education in mild form of Alzheimer's disease: The cognitive reserve theory
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Inverse association between CSF Aβ 42 levels and years of education in mild form of Alzheimer's disease: The cognitive reserve theory
چکیده انگلیسی

In Alzheimer's disease (AD), the cognitive reserve theory predicts that at any level of assessed clinical severity, the underlying brain pathology is more advanced in patients with more cognitive reserve. Recent evidences suggest that cerebrospinal fluid (CSF) biomarkers may reflect the brain pathology in AD. We investigated the relationship between education level and CSF concentrations of β-amyloid, total tau and phosphorylated tau (ptau-181) in a cohort of 70 subjects newly diagnosed with AD. We report that CSF concentration of β-amyloid was inversely associated with years of education, after adjustment for age, sex, and severity of the disease. We further demonstrate in stratified analysis that this relation was mainly present in mild form of the disease (CDR1), and was attenuated in more advanced forms of the disease. These results are consistent with the cognitive reserve theory, and suggest that cognitive reserve may be protective against amyloid related cognitive impairment at the onset of the clinical dementia.

Research highlights
► Higher education was associated with lower CSF β-amyloid levels in Alzheimer's disease.
► This relation was mainly present in mild form of the disease.
► These results are consistent with the cognitive reserve theory.
► Cognitive reserve may be protective against amyloid related cognitive impairment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Disease - Volume 40, Issue 2, November 2010, Pages 456–459
نویسندگان
, , , , , , , , ,