کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3070146 1580726 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inhibition of peripheral TNF can block the malaise associated with CNS inflammatory diseases
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Inhibition of peripheral TNF can block the malaise associated with CNS inflammatory diseases
چکیده انگلیسی

Circulating cytokine levels are elevated in many neuropathologies and may be a cause of the associated malaise and depression. Using a rat model, we demonstrate that sickness behaviors generated by microinjection of IL-1β into the anterior hypothalamus are adopted by naive recipient animals following plasma transfer. We further show that neutralizing peripheral TNF by etanercept (a p75 TNF receptor/Fc fusion protein) prior to the IL-1β microinjection inhibits certain IL-1β-mediated sickness behaviors, such as the depression of open-field activity and reduced glucose consumption. IL-1β-induced central lesions induce peripheral TNF as part of the acute-phase response, and this appears to be the principal target of the etanercept. Thus behavioral changes induced by CNS lesions may result from peripheral expression of cytokines that can be targeted with drugs which do not need to cross the blood-brain barrier to be efficacious.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Disease - Volume 32, Issue 1, October 2008, Pages 125–132
نویسندگان
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