کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3070633 | 1580751 | 2006 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Cooling produces minimal neuropathology in neocortex and hippocampus Cooling produces minimal neuropathology in neocortex and hippocampus](/preview/png/3070633.png)
Cooling is a potential treatment for several neurological diseases. We have examined rodent and cat neocortex, cooled to 5 and 3°C, respectively, to identify a lower limit for safely cooling brain. Rat neocortex, intermittently cooled with a thermoelectric device for 2 h, showed no signs of neuronal injury after cresyl violet or TUNEL staining. Neurons were also preserved in cat cortex cooled for up to 2 h daily for 10 months. Cooled rat and cat cortex showed glial proliferation, but this was also observed in sham-operated rat cortex. When hippocampal slices from mice expressing the Green Fluorescent Protein (GFP) in neurons were cooled to 5°C, but not higher temperatures, we saw reversible dendritic beading and spine loss after 15–30 min. While there may be biochemical and functional alterations in brain cooled as low as 5°C, the neuropathological consequences of brain cooling appear to be insignificant.
Journal: Neurobiology of Disease - Volume 23, Issue 3, September 2006, Pages 637–643