کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3070865 1580749 2006 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mechanical hyperalgesia correlates with insulin deficiency in normoglycemic streptozotocin-treated rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Mechanical hyperalgesia correlates with insulin deficiency in normoglycemic streptozotocin-treated rats
چکیده انگلیسی
The triggers and pathogenesis of peripheral diabetic neuropathy are poorly understood, and this study evaluated the role of insulinopenia in nociceptive abnormalities in the streptozotocin (STZ) rat model of diabetes to test the hypothesis that, in addition to hyperglycemia, impairment of insulin signaling may be involved in progression of neuropathy. We measured blood glucose, plasma insulin, and sciatic nerve glucose and sorbitol levels, and withdrawal thresholds for hind limb pressure pain and heat pain in STZ-injected rats that developed hyperglycemia or remained normoglycemic. The pressure pain threshold did not change in vehicle-injected controls, but during the 2 weeks after STZ, it decreased by 25-40% in STZ-hyperglycemic and STZ-normoglycemic animals (P < 0.05). Mean heat pain threshold did not change in STZ-normoglycemic rats, but increased by about 1.5°C in STZ-hyperglycemic rats (P < 0.05). These pain thresholds did not correlate with blood or nerve glucose or sorbitol levels, but both correlated with plasma insulin level in STZ-normoglycemic rats, and low-dose insulin replacement normalized the pressure threshold without affecting blood glucose level. Thus, at least one of early signs of diabetic neuropathy in STZ-treated rats, mechanical hyperalgesia, can be triggered by moderate insulinopenia, irrespective of glycemic status of the animals.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Disease - Volume 24, Issue 2, November 2006, Pages 384-394
نویسندگان
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