کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3071507 1188517 2009 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Microdiálisis de alta resolución. Aspectos metodológicos y aplicación al estudio de la respuesta inflamatoria cerebral
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Microdiálisis de alta resolución. Aspectos metodológicos y aplicación al estudio de la respuesta inflamatoria cerebral
چکیده انگلیسی
Cerebral microdialysis is a tool that provides very relevant information in the metabolic monitoring of brain injured patients. It is a particularly effective technique for the detection and analysis of small molecules, given that the pores of the dialysis membrane act as a barrier to restrict the transport of larger species, such as proteins and other macromolecules. The recent availability of microdialysis catheters with membrane pores of larger size, termed “high resolution” catheters, would widen the spectrum of molecules detectable in the dialisate. However, there are technical complications related to the use of these catheters for such purposes, and therefore, this potential capacity for the recovery of proteins needs to be validated, in order to begin its application as a tool in studies of proteomics associated with brain injuries. The following review depicts the basic principles of microdialysis, and describes some of the issues involved in the recovery of molecules in the dialisate, including the physical properties of the dialysis membrane and of the molecules of interest.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurocirugía - Volume 20, Issue 5, 2009, Pages 433-447
نویسندگان
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