کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3095845 | 1581475 | 2013 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Gamma Knife Radiosurgery for Symptomatic Brainstem Intra-Axial Cavernous Malformations Gamma Knife Radiosurgery for Symptomatic Brainstem Intra-Axial Cavernous Malformations](/preview/png/3095845.png)
ObjectiveThe purpose of this study was to evaluate the efficacy and safety of gamma knife radiosurgery (GKRS) for the treatment of symptomatic brainstem intra-axial cavernous malformations (CMs) associated with high surgical morbidity.MethodsTwenty-one patients with symptomatic brainstem intra-axial CMs were treated by GKRS between 2005 and 2010. One patient was lost to follow-up. The median age of the patients was 39.5 years (range, 24−69 years). All patients had experienced 1 or more symptomatic hemorrhages before GKRS (range, 1−3). The median marginal radiation dose was 13 Gy, and the median volume of the malformation was 0.56 mL. The median follow-up period after radiosurgery was 32 months (range, 12−82 months; mean, 38.9 months).ResultsBefore GKRS, 31 hemorrhages (1.55 per patient) were observed. The annual hemorrhage rate before GKRS was 39.5%, excluding the first hemorrhage. After GKRS, 1 hemorrhage (0.05 per patient) was identified. It occurred 6 months after radiosurgery. The patient showed complete recovery to a premorbid status with steroid medication. The annual hemorrhage rate after GKRS was 8.2% for the first 2 years. After the expected latency period, no hemorrhages were identified. One patient (5%) exhibited permanent paresthesia, which was a new neurologic symptom in absence of any hemorrhagic event, after the radiosurgery.ConclusionsGKRS seems to be relatively effective and safe for reducing the rebleeding rate of brainstem intra-axial CMs that have high surgical risk. Careful selection of a low marginal dose and an optimal radiosurgical technique are helpful to achieve good outcomes.
Journal: World Neurosurgery - Volume 80, Issue 6, December 2013, Pages e261–e266