کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3097824 | 1190952 | 2010 | 6 صفحه PDF | دانلود رایگان |
BackgroundAccurate assessment of therapeutic response in patients with brain abscess (BA) is essential to direct appropriate therapy. This study was performed with an aim to see the treatment-induced changes in diffusion tensor imaging (DTI) indices (ie, fractional anisotropy [FA] and mean diffusivity [MD]) in follow-up patients with BA after treatment.MethodsTwenty patients with BA were prospectively studied in this study. Diffusion tensor imaging in first follow-up was done in all after 1 week and in 6 at 4 weeks of the initial study.ResultsThe mean FA and MD values in first, second, and third studies were 0.28 ± 0.03 and (0.81 ± 0.07) × 10−3 mm2/s, 0.18 ± 0.09 and (1.08 ± 0.09) × 10−3 mm2/s, and 0.13 ± 0.04 and (0.99 ± 0.13) × 10−3 mm2/s, respectively. The FA value was significantly (P < .01) decreased along with no significant change in MD value (P = .08) for 3 study periods. The mean volume (in milliliter) of the abscesses was 2.14 ± 1.04, 1.34 ± 0.45, and 0.77 ± 0.14 in first, second, and third studies, respectively.ConclusionsWe conclude that the reduction in FA value reflects the down-regulation of the neuroinflammatory molecules in response to treatment in patient with BA and may be used to assess therapeutic response in these patients in future.
Journal: World Neurosurgery - Volume 73, Issue 1, January 2010, Pages 63–68