کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3121261 1583373 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cephalometric changes produced by locally applied anabolic steroid in Wistar rats
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Cephalometric changes produced by locally applied anabolic steroid in Wistar rats
چکیده انگلیسی

Background and objectiveThere is a strong relationship between neuromuscular activity and facial skeletal morphogenesis. The systemic use of anabolic steroid accelerates craniofacial growth and induces high functional activity of rats’ masticatory muscles. The present study examines the effect of an anabolic steroid locally applied in the masseter muscle of growing rats with the purpose of verifying possible craniofacial changes with minimum drug side effects, using cephalometric analysis.Materials and methodsForty-three 3-week-old Wistar rats were evaluated and divided into two groups: (1) NAN group (local bilateral masseter injection of nandrolone decanoate – 0.05 μg/3 μl/bi-weekly) and (2) CON group (local bilateral masseter injection of sterile oil – 3 μl). Tukey and Wilcoxon tests were used.ResultsIn NAN group the cephalometric measures showed horizontalized facial growth (reduce of FMA angle –p < 0.01), increase of posterior facial height, decrease of anterior facial height, reduction of gonial angle (p < 0.05), increase of mandibular height (p < 0.01). There was no variation in the length of the mandible, in the skull and animals’ weight gain, thus demonstrating that no important systemic effect occurred.ConclusionThe local injection of nandrolone in the masseter muscle of rats was capable to alter the growth direction and the morphology of the craniofacial complex in Wistar rats.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Oral Biology - Volume 54, Issue 4, April 2009, Pages 389–395
نویسندگان
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