کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3121618 1583403 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Deterioration of the Langerhans cell network of the human gingival epithelium with aging
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Deterioration of the Langerhans cell network of the human gingival epithelium with aging
چکیده انگلیسی

SummaryDendritic cells (DCs) are the professional antigen-presenting cells responsible for initiating of the immune response. Langerhans cells (LCs) are a type of DC that is a permanent resident of the oral epithelium. LCs are organized conforming a network in such a way as to maximize their surface area for efficient apprehension of antigens. To detect age-related changes in the LCs network, fragments of gingival epithelium spontaneously accompanying dental removals were processed by immunohistochemistry. Monoclonal antibody CD1a followed by biotinized immunoglobulin–streptoavidin peroxidase were used to identify the LCs with the light microscope. LC density and LC types were analyzed according to their morphology and intraepithelial distribution. In the older age group (61–74 years) the density was significantly lower than in the younger age groups. Morphologically, LCs showed fewer dendritic-branching processes and had a rounded shape in the older age group.Present observations indicate that the LC network changes markedly with aging. These results suggest that immunological defense of the oral tissue might be compromised in old age.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Oral Biology - Volume 51, Issue 12, December 2006, Pages 1150–1155
نویسندگان
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