کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3121712 1583375 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The association of MMP-9 and IL-18 gene promoter polymorphisms with gingivitis in adolescents
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
The association of MMP-9 and IL-18 gene promoter polymorphisms with gingivitis in adolescents
چکیده انگلیسی

ObjectiveInterleukin 18 (IL-18) is shown to be a proinflammatory cytokine that regulates the expression of matrix metalloproteinase 9 (MMP-9). The aim of this study was to test for differences between Czech adolescents with and without gingivitis in relation to MMP-9 and IL-18 polymorphisms.DesignA total of 298 Caucasian children, aged 11–13 years, were examined to assess gingival health. DNA for genetic analysis was obtained from buccal epithelial cells, and the MMP-9 −1562C/T and IL-18 −607A/C variants were identified with PCR-RFLP.ResultsGingivitis was present in 49.3% of the adolescents examined, the rest of the group was considered healthy. The IL-18 −607C and MMP-9 −1562T alleles were found in 58.9% and 8.3% of the healthy subjects, and in 62.2% and 15.0% of the patients with gingivitis, respectively. Although differences in allele frequencies were not significant for IL-18 variant, they were significant for MMP-9 polymorphism (p = 0.01, pcorr < 0.05). Furthermore, a highly significant association of the composite genotype (formed by the variants of the both genes) with gingivitis was found (p = 0.004, pcorr < 0.05).ConclusionsThe −1562 T allele of MMP-9 gene could have a role in gingivitis in adolescents. In addition, interaction of the MMP-9 and IL-18 genes could be considered a risk factor for the development of gingivitis in children.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Oral Biology - Volume 54, Issue 2, February 2009, Pages 172–178
نویسندگان
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