کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3121789 | 1583381 | 2008 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Effect of experimental diabetes on craniofacial growth in rats Effect of experimental diabetes on craniofacial growth in rats](/preview/png/3121789.png)
ObjectivesThe goal of this study was to assess the effect of type 1 diabetes mellitus (T1DM) on the craniofacial growth and skeletal maturation using the STZ-DM rat model.DesignExperimental T1DM was induced in 3-week-old male Wistar rats by a single dose of 60 mg/kg body weight of streptozotocin (STZ). Lateral and dorsoventral X-rays of the head were taken at the age of 7 weeks. The X-rays were scanned, digitised and selected linear distances were measured and analysed statistically.ResultsIn STZ-DM statistical analysis of results revealed a reduction in growth of most of the linear measurements in the neurocranium and mandible by X-ray analysis, and all measurements were significantly lower in viscerocranium.ConclusionsUncontrolled T1DM reduces craniofacial growth, resulting in retardation of skeletal development.
Journal: Archives of Oral Biology - Volume 53, Issue 9, September 2008, Pages 819–825