کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3121895 1583386 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of noxious stimulation of orofacial tissues on rat licking behaviour
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Effects of noxious stimulation of orofacial tissues on rat licking behaviour
چکیده انگلیسی

ObjectiveSince there is limited information of the effects of orofacial pain on oromotor behaviour, the aim of this study was to test the effects of injection of the algesic chemical glutamate into orofacial tissues on licking behaviour in rats.DesignMale Sprague-Dawley rats were trained to carry out stereotyped licking from a water spout connected to a force transducer, and once they met preset licking motor requirements (peak force of licking of 2–20 g, interlick interval of 0.11–0.19 s), their masseter muscle or tongue was injected with either isotonic saline (0.9%, 5 μL) or glutamate (1.0 M, 5 μL) and several parameters of their licking performance were re-assessed.ResultsThere were significant effects (P < 0.05; 1-way repeated measures ANOVA) of glutamate injection into the tongue on the number of clusters of licks, the number of licks per cluster, the intercluster period, the peak force of licking and the interlick interval, but there were no significant (P > 0.05) effects on licking of isotonic saline injection into the tongue or isotonic saline or glutamate injection into the masseter muscle.ConclusionsThese findings provide the first documentation that noxious stimulation of the tongue, but not of the masseter muscle, has a modulatory effect on licking behaviour in the rat and suggest that the neural substrate for licking may be sensitive to selective nociceptive inputs from the orofacial region.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Oral Biology - Volume 53, Issue 4, April 2008, Pages 361–368
نویسندگان
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