کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3121909 1583411 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Radioimmunoassay quantification of adrenomedullin in human gingival crevicular fluid
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Radioimmunoassay quantification of adrenomedullin in human gingival crevicular fluid
چکیده انگلیسی

SummaryObjectiveTo investigate whether adrenomedullin (ADM), a multifunctional peptide with key roles in host antimicrobial defence and inflammation, was present and quantifiable in human gingival crevicular fluid (GCF) and to study its relationship with periodontal health and disease.DesignGCF samples (30 s) were collected using perio-paper strips from one diseased site in 21 subjects with periodontal disease and one healthy site from 19 control subjects with no evidence of periodontal disease. Samples were analysed by radioimmunoassay using a specific anti-human ADM antibody.ResultsMeasurable adrenomedullin-like immunoreactivity (ADM-LI) was present in all the GCF samples collected. ADM-LI was significantly higher in periodontitis sites (mean 493.6 pg) than in control healthy sites (mean 248.5 pg), p = 0.0016.ConclusionIt is concluded that ADM is present in GCF at levels at which it could have an antibacterial role in the gingival crevice and modulate the pathophysiology of periodontal inflammation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Oral Biology - Volume 51, Issue 4, April 2006, Pages 334–338
نویسندگان
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