Stromal-cell-derived factor 1: Potentially an important promoter in healing of tooth extraction or dental implantation to stimulate the host healing mechanism?

Wound healing after tooth extraction or dental implantation is an intricate process involving a series of biological events involving tissue repair and remodeling in response to injury. The healing process is greatly influenced by a variety of systemic and local factors. Wound failure remains a clinical problem that causes pain, dry socket, or other complications, and it can even affect dental implants and prosthodontic treatment. Numerous studies have demonstrated that stromal-cell-derived factor 1 (SDF-1) is an active chemokine for repair of injured blood vessels, and the SDF-1/CXCR4 signaling pathway might play an important role in repairing injured tissue by promoting host-cell recruitment and angiogenesis. In this article, the effectiveness of SDF-1 for enhancing wound healing is evaluated. It's hypothesized that increasing localized concentration of SDF-1 will contribute to the acceleration of wound healing after tooth extraction or dental implantation treatments, especially in diabetic and elderly patients.