کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3144546 1196949 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Radiation caries in nasopharyngeal carcinoma patients after intensity-modulated radiation therapy: A cross-sectional study
ترجمه فارسی عنوان
پوسیدگی رادیویی در بیماران مبتلا به سرطان نازوفارنکس پس از پرتودرمانی شدید مدولاسیون: مقطعی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
چکیده انگلیسی

Background/purposeThe exact dose of intensity-modulated radiation therapy (IMRT) associated with tooth damage is mostly unknown. We aim to evaluate the severity of dental lesions after IMRT and the correlation with the radiation dose to the dentition in patients with nasopharyngeal carcinoma (NPC).Materials and methodsThis was a cross-sectional study of 42 patients with NPC who completed IMRT in 2011. Each premolar tooth was divided into 13 sites. Teeth were evaluated using a validated index and subsequently categorized at each divided site. The relationship between dose distribution and the caries severity score was analyzed using logistic models. The odds of developing caries damage were evaluated using odds ratios.ResultsA total of 4342 sites from 334 premolar teeth were evaluated. For sites exposed to 30–60 Gy, the odds of developing caries damage were 12–200 times greater compared with sites unexposed to IMRT. A new radiation caries lesion was likely to occur when the dose was >35.8 Gy after 17 days' radiation therapy (P < 0.05).ConclusionThe findings suggest that new tooth damage was likely to occur at doses > 35.8 Gy, and care should be taken throughout the treatment planning process to limit tooth doses to < 50 Gy in NPC patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Dental Sciences - Volume 11, Issue 1, March 2016, Pages 1–7
نویسندگان
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