کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3144845 | 1196999 | 2011 | 5 صفحه PDF | دانلود رایگان |
Background/purposeOral squamous cell carcinoma (OSCC) is highly prevalent worldwide. Lysyl oxidase (LOX) is an important enzyme that modulates the extracellular matrix. The LOX superfamily contains LOX and LOX-like (LOXL) enzymes. The aim of the present study was to determine the expressions of LOXL genes in OSCC.Materials and methodsRT-PCR was performed to detect messenger (m)RNA expression of the LOXL genes, LOX-L1, -L3, and -L4, in paired OSCC and non-cancerous matched tissues (NCMTs).ResultsIncreased mRNA expressions of LOX-L1 and LOX-L3 in OSCC relative to NCMTs were identified in 41% and 65% of OSCC samples, respectively. The normalized mRNA expression of LOXL-3 was 1.11 ± 0.15 in OSCC, which was significantly higher than 0.68 ± 0.12 in NCMTs (P = 0.004). The increased expression of LOX-L3 was associated with worse survival of OSCC patients (P = 0.028).ConclusionThe results indicated the frequent increase in LOX-L3 mRNA expression in OSCC, and the value of LOX-L3 mRNA expression might have clinical uses in monitoring OSCC.
Journal: Journal of Dental Sciences - Volume 6, Issue 4, December 2011, Pages 205–209