کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3145713 | 1197097 | 2012 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Phenytoin- and amlodipine-induced gingival overgrowth Phenytoin- and amlodipine-induced gingival overgrowth](/preview/png/3145713.png)
Drug-induced gingival overgrowth is an adverse event associated with three types of drugs, i.e., anticonvulsants, immunosuppressants, and calcium-channel blockers. It was shown that the combined use of an immunosuppressant (cyclosporine) and a calcium-channel blocker increases the prevalence and severity of gingival overgrowth. However, few reports discussed the effects of the combination of an anticonvulsant (phenytoin) and a calcium-channel blocker (amlodipine). In this case report, we present an epilepsy patient who was using both phenytoin and amlodipine, which caused extensive gingival overgrowth. After periodontal treatment and a gingivectomy, the gingival overgrowth was significantly reduced. A postoperative drug-substitution regimen and intensive professional care ensured a stable result 1 year after surgery.
Journal: Journal of Dental Sciences - Volume 7, Issue 1, March 2012, Pages 85–88