Simvastatin Suppresses Osteoblastic Expression of Cyr61 and Progression of Apical Periodontitis through Enhancement of the Transcription Factor Forkhead/Winged Helix Box Protein O3a

Simvastatin may alleviate periapical lesions by enhancing FoxO3a activity to suppress the synthesis of Cyr61 in osteoblasts. Moreover, the downstream effector mechanism of Cyr61 may involve CCL2 production and macrophage recruitment.