Wegener's Granulomatosis

Wegener's granulomatosis (WG) is a rare systemic disease associated with necrotizing granulomatous inflammation in the upper and lower respiratory tract, glomerulonephritis, and vasculitis. Generalized and limited forms are recognized, and both may present with nonspecific symptoms early in the process. Oral, sinus, and cutaneous findings commonly are seen at initial presentation and/or during the course of the disease. Early diagnosis and treatment are necessary to limit the potentially serious complications associated with WG. This article includes information pertaining to recognition, diagnosis, and management of WG to aid the clinician in early diagnosis and institution of therapy to limit these complications.