کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3164464 1198792 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Treatment outcome of patients with stages I–II nasopharyngeal carcinoma after late course accelerated hyperfractionation radiotherapy alone
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Treatment outcome of patients with stages I–II nasopharyngeal carcinoma after late course accelerated hyperfractionation radiotherapy alone
چکیده انگلیسی

SummaryObjectivesTo follow up the efficacy and incidence of radiation-induced complications of late course accelerated fractionation (LCAF) radiotherapy in early-stage nasopharyngeal carcinoma (NPC).Materials and methodsFrom December 1995 to November 2002, 158 patients with stages I–II NPC were admitted for radiotherapy alone. For the first two-thirds of the treatment, 2 daily fractions of 1.2 Gy were given to the primary lesion, 5 days per week to a total dose of 48 Gy/40 fractions, over a period of 4 weeks. From the 5th week, an accelerated hyperfractionation schedule was carried out. Two daily fractions of 1.5 Gy were given, to a total dose of 30 Gy/20 fractions over 2 weeks. Thus the total dose was 78 Gy in 60 fractions in 6 weeks.ResultsAll patients completed the treatment. Acute mucositis: none in 3 patients, grade 1 in 32, grade 2 in 69, grade 3 in 51, and grade 4 in 3 patients. Five-year nasopharyngeal control and overall survival (OS) rate of T1 and T2 were 97.8%, 90.2% (p = 0.380) and 88.6%, 81.4% (p = 0.252), respectively. Five-year OS in N0 and N1 patients were 86.5% and 81.9% (p = 0.033), respectively. Thirty-eight patients died, and the main cause of death was distant metastasis. Seventeen (11%) patients had radiation-induced cranial nerve palsy.ConclusionWith LCAF, treatment-related toxicities were acceptable. Five-year nasopharyngeal control and OS in T2 stage were improved. Main cause of death was distant metastasis. Patients with N1 had a relatively lower survival rate, which suggested that chemotherapy might be indicated for those patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Oncology - Volume 48, Issue 10, October 2012, Pages 1058–1063
نویسندگان
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