کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
316966 1432586 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mechanisms linking depression co-morbid with obesity: An approach for serotonergic type 3 receptor antagonist as novel therapeutic intervention
ترجمه فارسی عنوان
مکانیسم هایی که باعث افسردگی می شوند همبستگی با چاقی: یک رویکرد برای آنتاگونیست گیرنده سروتونرژیک نوع 3 به عنوان درمان جدید درمان
کلمات کلیدی
افسردگی، چاقی، لپتین، گلوکز پلاسما تغییر یافته، کورتیکواسترون
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


• Obesity heightens the risk for depression.
• Mechanisms for depression co-morbid with obesity remains ill defined.
• HPA-axis hyperactivity is involved in depression co-morbid with obesity.
• Leptin and insulin resistance, reduced BDNF concentration is also observed.
• 5-HT3 antagonists act through serotonergic modulation.

Despite of the enormous research, therapeutic treatment for depression has always been a serious issue. Even though depression and obesity are individual abnormal health conditions, each act as a triggering factor for the other. Obese individuals are twice prone to develop depression than that of non-obese persons. The exact mechanism how obesity increases the risk for depression still remains an area of interest for research in neuropsychopharmacology. Depression and obesity share some common pathological pathways such as hyperactivity of hypothalamic-pituitary-adrenal (HPA) axis, dysregulation of oxidant/antioxidant system balance, higher level of inflammatory cytokines, leptin resistance, altered plasma glucose, insulin resistance, reduced neuronal brain derived neurotrophic factor (BDNF) and decreased serotonergic neurotransmission in various regions of brain. The antidepressant-like effect of 5-HT3 receptor antagonists through allosteric modulation of serotonergic pathways is well evident from several research investigations belonging to our and some in other laboratories. Furthermore, serotonin regulates diet intake, leptin, corticosterone, inflammatory mechanisms, altered plasma glucose, insulin resistance and BDNF concentration in brain. The present review deals with various biological mechanisms involved in depression co-morbid with obesity and 5-HT3 receptor antagonists by modulation of serotonergic system as a therapeutic target for such co-morbid disorder.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Asian Journal of Psychiatry - Volume 17, October 2015, Pages 3–9
نویسندگان
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