کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3170840 1199821 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cancer stem cells in head and neck squamous cell carcinoma
ترجمه فارسی عنوان
سلول های بنیادی سرطانی در کارسینوم سلول سنگفرشی سر و گردن
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
چکیده انگلیسی
Recent studies have demonstrated that cancer stem cells (CSC) play an important role in the pathobiology of head and neck squamous cell carcinomas (HNSCC). This subpopulation of undifferentiated, self-renewing cells is responsible for resistance to conventional anti-cancer therapy, cancer recurrence, metastasis and ability to form a heterogeneous tumor. CSC are identified on the basis of specific markers, including membrane proteins or cell enzymes, or by using their self-renewal properties. As their resistance to standard HNSCC treatment may eventually lead to the lack of treatment success, there is an urgent need to better understanding CSC biology and identify them as potential target new treatment modality.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Otolaryngologia Polska - Volume 68, Issue 3, May–June 2014, Pages 105-111
نویسندگان
, ,