کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3176644 | 1200274 | 2012 | 6 صفحه PDF | دانلود رایگان |

BackgroundPrevious studies have shown an inconsistent association between sleep duration and hypercholesterolaemia. This study examined the association between sleep duration and hypercholesterolaemia in a nationally representative sample of US adults.MethodsA cross-sectional study of 16,652 participants in the 2008 National Health Interview Survey (aged ⩾18 years, 52.5% women) was conducted. Sleep duration was categorized as ⩽5, 6, 7, 8, or ⩾9 h. Hypercholesterolaemia (n = 5578) was assessed by questionnaire.ResultsA significant gender difference was found in the association between sleep duration and hypercholesterolaemia (P interaction = 0.003). Among women, sleep duration ⩽5 h was positively associated with hypercholesterolaemia after adjusting for potential confounders and mediators including physical activity, psychological distress, body mass index, diabetes mellitus, and hypertension. Compared with a sleep duration of 7 h (referent), the multivariate odds ratio (OR) of hypercholesterolaemia was 1.27 (95% confidence interval [CI] 1.04–1.54) for sleep duration ⩽5 h. In contrast, among men, sleep duration ⩾8 h was inversely associated with hypercholesterolaemia. Compared with a sleep duration of 7 h (referent), the multivariate OR of hypercholesterolaemia was 0.80 (95% CI 0.69–0.94) and 0.78 (95% CI 0.60–1.00) for sleep durations of 8 and ⩾9 h, respectively. In subgroup analyses, the positive association between sleep duration ⩽5 h and hypercholesterolaemia in women, and the inverse association between sleep duration ⩾8 h and hypercholesterolaemia in men, were more pronounced among those aged <60 years and race/ethnic groups other than non-Hispanic Whites.ConclusionSleep duration ⩽5 h was positively associated with hypercholesterolaemia in women, whereas sleep duration ⩾8 h was inversely associated with hypercholesterolaemia in men.
Journal: Sleep Medicine - Volume 13, Issue 2, February 2012, Pages 145–150