کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3177350 | 1200298 | 2009 | 7 صفحه PDF | دانلود رایگان |

BackgroundPediatric OSA is associated with substantial morbidity in cognitive function. However, for any given OSA severity level, altered cognitive performance may or may not be present. Since IGF-1 is neuroprotective, we hypothesized that higher systemic IGF-1 levels may identify children at lower susceptibility for cognitive morbidity.MethodsConsecutive habitually snoring and non-snoring children ages 5–7 years were recruited from the community, and underwent overnight polysomnography, and neurocognitive testing and a blood draw the next morning. Snoring children were divided into OSA or no OSA, and OSA children were further subdivided into those with ⩾2 abnormal cognitive subtests and into those with normal cognitive scores. Plasma levels of IGF-1 were also measured using ELISA.ResultsAmong snoring children without OSA, circulating IGF-1 was 910 ± 110 pg/mL compared with 1070 ± 240 pg/mL in those with OSA (p < 0.01). However, IGF-1 was 540 ± 70 pg/mL in children with OSA and cognitive deficits, compared to 1370 ± 170 μg/L in children with OSA and normal cognitive scores (p < 0.001).ConclusionsIGF-1 levels are higher in children with OSA, particularly in those who do not manifest neurocognitive deficits, suggesting that the magnitude of the IGF-1 response elicited by OSA may play a significant protective role against the neurocognitive dysfunction associated with OSA.
Journal: Sleep Medicine - Volume 10, Issue 2, February 2009, Pages 167–173