کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3177800 1200316 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Thyroxine replacement therapy reverses sleep-disordered breathing in patients with primary hypothyroidism
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Thyroxine replacement therapy reverses sleep-disordered breathing in patients with primary hypothyroidism
چکیده انگلیسی

Background and purposeAnecdotal reports suggest that sleep-disordered breathing (SDB) is common among patients with primary hypothyroidism. This study was undertaken to determine the prevalence of SDB and to evaluate the effect of thyroxine replacement therapy on SDB in patients with primary hypothyroidism.Patients and methodsFifty consecutive newly diagnosed, untreated symptomatic patients with primary hypothyroidism (age: 34±11 years; males: 21 [42%]) were prospectively studied. Physical examination, anthropometry, fasting blood glucose and serum lipids were performed in all patients at baseline. Polysomnography was done at baseline in all patients and was repeated after adequate thyroxine replacement in those who had SDB.ResultsSDB defined as apnea–hypopnea index (AHI) ≥5 was present in 15 patients (30%) at baseline and was reversible in 10 of the 12 patients evaluated following thyroxine replacement therapy (P=0.006). Thyroxine replacement therapy was associated with improvement in findings that reflect a compromised upper airway, such as macroglossia (4 [33%] vs. 1 [8%]; P=0.083), myoedema (5 [42%] vs. 1 [8%]; P=0.046) and facial puffiness (10 [83%] vs. 1 [8%]; P=0.003).ConclusionsReversible SDB is common among patients with primary hypothyroidism. Changes in upper airway anatomy resulting from hypothyroidism probably contribute to the development of SDB in these patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sleep Medicine - Volume 7, Issue 1, January 2006, Pages 55–61
نویسندگان
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