کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
319249 | 539256 | 2007 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synergistic effects of tandospirone and selective serotonin reuptake inhibitors on the contextual conditioned fear stress response in rats Synergistic effects of tandospirone and selective serotonin reuptake inhibitors on the contextual conditioned fear stress response in rats](/preview/png/319249.png)
The purpose of this study was to investigate the effects of co-administration of tandospirone (a 5-HT1A receptor agonist) and individual selective serotonin reuptake inhibitors (SSRIs) on the contextual conditioned fear stress, using an anxiety model in rats. One day after fear conditioning, tandospirone (0.3–3 mg/kg, s.c.), paroxetine (5–20 mg/kg, i.p.), fluvoxamine (30–60 mg/kg, i.p.) and citalopram (3–30 mg/kg, i.p.) significantly inhibited the conditioned freezing in a dose-dependent manner, whereas, 14 days after fear conditioning, the anxiolytic effects of these drugs were weakened. Fourteen days after fear conditioning, co-administration of tandospirone (0.3 mg/kg, s.c.) with each SSRI [paroxetine (5 mg/kg, i.p.), fluvoxamine (30 mg/kg, i.p.) and citalopram (10 mg/kg, i.p.)], given at subeffective doses, markedly inhibited the conditioned freezing without affecting the locomotor activities and CYP3A4-related pharmacokinetic drug–drug interaction. These results elucidate the pharmacodynamic synergistic effects of tandospirone and SSRIs. Therefore, this augmentation therapy (SSRI + 5-HT1A receptor agonist) may prove useful for some anxiety disorders.
Journal: European Neuropsychopharmacology - Volume 17, Issue 10, October 2007, Pages 643–650