کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
320906 539746 2008 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cannabinoid and opioid modulation of social play behavior in adolescent rats: Differential behavioral mechanisms
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Cannabinoid and opioid modulation of social play behavior in adolescent rats: Differential behavioral mechanisms
چکیده انگلیسی

We have recently shown that the pharmacological mechanisms through which cannabinoid and opioid drugs influence social play behavior in adolescent rats can be partially dissociated. Here, we characterize the effects of the direct cannabinoid agonist WIN55,212-2, the indirect cannabinoid agonist URB597 and the opioid agonist morphine on social play at the behavioral level. By treating either one or both partners of the test dyad, we show that these drugs differentially affect play solicitation and play responsiveness. By testing these drugs in animals which were either familiar or unfamiliar to the test cage, we show that environmental factors differentially modulate the effects of cannabinoid and opioid drugs on social play. These results support and extend our previous findings suggesting that, although cannabinoid and opioid systems interact in the modulation of social play behavior in adolescent rats, they do so through partially dissociable behavioral and pharmacological mechanisms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 18, Issue 7, July 2008, Pages 519–530
نویسندگان
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