کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
321166 539767 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Response to SSRIs and role of the hormonal therapy in post-menopausal depression
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Response to SSRIs and role of the hormonal therapy in post-menopausal depression
چکیده انگلیسی

The aim of this study is to prospectively evaluate the antidepressant response to SSRIs in depressed post-menopausal women with or without hormonal therapy (HT), and to analyze the possible influence of basal serum levels of gonadotropins and sexual hormones on the antidepressant response. 170 post-menopausal women with a depressive episode (DSM-IV criteria) – 47 on HT and 123 not on HT – started the treatment with an SSRI. Depressive symptoms were assessed at baseline and 7 weeks thereafter by raters blind to treatment regimen. Response rates were 63.2% in the group without HT and 83.7% in the HT group (p = 0.013). An inverse correlation emerged between the basal levels of LH and the improvement in HRSD scores (p = 0.001) in the group without HT. In conclusion, HT appeared to improve the antidepressant response to SSRIs. Furthermore, in post-menopausal women, LH basal levels may be taken into account as possible predictor of response.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 17, Issues 6–7, May–June 2007, Pages 400–405
نویسندگان
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