کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
321933 | 539881 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
MDMA reinstates cocaine-seeking behaviour in mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Background:MDMA effects are mediated by monoaminergic systems, which seem to play a central role in cocaine craving and relapse.Methods:CD1 mice trained to self-administer cocaine (1 mg/kg/infusion) underwent an extinction procedure in which the cues contingent with drug self-administration remained present. Mice achieving extinction were injected with MDMA (10 mg/kg), d-amphetamine (1 and 2 mg/kg) or saline and tested for reinstatement.Results:Acute MDMA, but not d-amphetamine or saline reinstated cocaine-seeking behaviour in mice in which cocaine self-administration and contingent cues were previously extinguished.Conclusions:Acute MDMA can reinstate cocaine-seeking behaviour in mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 19, Issue 6, June 2009, Pages 391–397
Journal: European Neuropsychopharmacology - Volume 19, Issue 6, June 2009, Pages 391–397
نویسندگان
José Manuel Trigo, Maria Juliana Orejarena, Rafael Maldonado, Patricia Robledo,