کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
323200 540526 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Epigenetic marking of the BDNF gene by early-life adverse experiences
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Epigenetic marking of the BDNF gene by early-life adverse experiences
چکیده انگلیسی

Studies over the past half-century have made it clear that environmental influences in development, particularly stress and traumatic experiences, can remain pervasive across the lifespan. Though it has been hypothesized for some time that the long-term consequences of early-life adversity represent epigenetic influences, it has not been until recently that studies have begun to provide empirical support of experience-driven epigenetic modifications to the genome. Here we focus on this theme, and review current knowledge pertaining to the epigenetics of behavioral development. At the center of our discussion is the brain-derived neurotrophic factor (BDNF) gene, as abnormal BDNF gene activity is a leading etiological hypothesis by which early-life adverse experiences persistently modify brain and behavioral plasticity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hormones and Behavior - Volume 59, Issue 3, March 2011, Pages 315–320
نویسندگان
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