کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3256965 | 1207381 | 2013 | 10 صفحه PDF | دانلود رایگان |
• Intestinal IL-17/22 cells in gluten-sensitive primates consist of T and Lin − cells.
• The IL-17-producing T cells also secrete IL-22, suggesting a synergism.
• Upon introduction of dietary gluten, IL-17/22-producing cells decline.
• IL-17/22 decline is paralleled with disruption of intestinal epithelial integrity.
Celiac disease (CD) is an autoimmune disorder caused by intolerance to dietary gluten. The interleukin (IL)-17 and IL-22 function as innate regulators of mucosal integrity. Impaired but not well-understood kinetics of the IL-17/22 secretion was described in celiac patients. Here, the IL-17 and IL-22-producing intestinal cells were studied upon their in vitro stimulation with mitogens in class II major histocompatibility complex-defined, gluten-sensitive rhesus macaques. Pediatric biopsies were collected from distal duodenum during the stages of disease remission and relapse. Regardless of dietary gluten content, IL-17 and IL-22-producing cells consisted of CD4 + and CD8 + T lymphocytes as well as of lineage-negative (Lin −) cells. Upon introduction of dietary gluten, capability of intestinal T cells to secrete IL-17/22 started to decline (p < 0.05), which was paralleled with gradual disruption of epithelial integrity. These data indicate that IL-17/22-producing cells play an important role in maintenance of intestinal mucosa in gluten-sensitive primates.
Journal: Clinical Immunology - Volume 147, Issue 1, April 2013, Pages 40–49